A general review on PBT inlcuding dosimetric advantage, clinical data on PBT for ocular tumor, skull base, paraspinal tumors (chondrosarcoma and chordoma), and unresectable sarcomas, reirradiation and pediatrics, as well as the expanded applications as treatment for malignancies of head and neck, lung, liver, breast and prostate.

This review also discussed the considerable challenges in PBT application touching upon technology development, dealing with anatomical changes and biological effectiveness.