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Radiation-induced skin and heart toxicity in patients with breast cancer treated with adjuvant proton radiotherapy: a comparison with photon radiotherapy.

October 2023
Executive summary

The active and inactive (pro-BNP and NT-proBNP) forms of BNP are classically used as biomarkers for diagnosing and monitoring acute and chronic heart failure. This study compared dosimetric data and incidence of toxicity in left breast cancer patients underwent proton-RT (n=24) and photon-RT (n=87). Proton-RT reduced doses to the heart and lungs and was associated with a lower rate of increased NT-proBNP than did photon-RT, however, proton-RT had a higher rate of radiation dermatitis (29%) than did photon RT (11%). 

Key content topics
Dosimetry
Toxicity
Top cancer treatments
Breast

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