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A phase II trial of hypofractionated high-dose proton beam therapy for unresectable liver metastases.

November 2022
Executive summary

This study analyzed 46 patients with 49 liver metastases treated by PBT to a total dose of 60 GyRBE in 5 fractions (BED 132 GyE) or 70 GyRBE in 10 (BED 119 GyE). The 1-year freedom from local progression rate in patients with lesion <3 cm was 87.4%, while that was 74.1% in patients with lesion > 3 cm (p = 0.087). One patient developed a grade 2 gastric ulcer. No patients developed grade ≥3 toxicities. The authors concluded that hypofractionated PBT with a BED > 100 GyRBE for liver metastasis is safe and effective. 

Key content topics
Dosimetry
Toxicity
Top cancer treatments
Gastro-intestinal

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