Trends in radiotherapy administration in the management of hepatocellular carcinoma: Analysis of a Korean tertiary hospital registry of hepatocellular carcinoma patients diagnosed between 2005 and 2017. This paper presented an increasing trend in the utilization of radiotherapy based on the registry data of patients newly diagnosed with HCC between January 2005 and December 2017 at the Samsung Medical Center. Of 9,132 patients newly diagnosed with HCC, 2,445 patients (26.8%) received radiotherapy for all lesions. The proportions of patients receiving radiotherapy as initial management (0.1% vs. 12.5%) increased dramatically. The majority of patients treated between 2018 and 2021 received proton beam therapy (43.6%). The OS of patients who received radiotherapy as initial management increased significantly (5-year OS: from 5.4% to 30.1%).