Published by the Upenn group, this study reported reduced xerostomia with FLASH proton compared to standard proton therapy in mice. The head and neck area of C57BL/6 mice was irradiated with a single dose of RT (ranging from 14-18 Gy) or a fractionated dose of 8 Gy x 3 of F-PRT (128 Gy/s) or standard proton therapy (0.95 Gy/s). Improvement in salivary flow and significantly increased overall survival were shown in mice treated with FLASH proton. The authors concluded that this modality could be useful for the clinical management of head and neck cancer patients.