Embryonal tumors with multilayered rosettes (ETMRs) are aggressive tumors that typically occur in young children. This study reported the outcomes of seven patients treated with proton therapy. Their median age at diagnosis was 33 months (range 10-57 months) and their median overall survival (OS) was 16 months (range 8-64 months), with three patients surviving 36 months or longer.

This study also included a literature review that of identified 204 cases of ETMR, the median OS of 10 months (range 0.03-161 months), and the median OS of 18 long-term survivors (≥36 months) in the literature was 77 months (range 37-184 months). The study concluded that the outcomes of patients with ETMR treated with proton therapy are encouraging compared to historical results.