In the context of definitive retreatment, increasing reRT dose can potentially improve OS and offer a chance of cure, particularly in patients with limited loco-regionally recurrent disease. However, retreatment can be challenging for fear of excessive toxicities and the inability to safely deliver definitive (≥60 Gy) doses. This review article examined the advanced radiation techniques including IMRT, SBRT and proton approach in reRT setting.

The review concluded that patient selection is critical in order to maximize the benefits of reRT. Prospective clinical studies are needed to optimize patient selection and to facilitate the integration of these different radiation modalities into the management of locally recurrent lung cancer.