This study by the Skandion Clinic group reported patient-reported fatigue and quality of life of 167 adults who received PBT for malignant brain tumors. No severe fatigue was recorded during the 36 months follow-up. At 12 months post PBT, higher mean dose to the brain, brainstem, hippocampi and pituitary was correlated to worsened physical fatigue. Reduced Motivation was correlated to higher radiation dose to the brainstem and the pituitary gland. At 36 months follow-up post-PBT, both Reduced Activity and Reduced motivation were correlated to higher radiation dose to the brain, brainstem and hippocampi.