Subtitle
Multivariate normal tissue complication probability models for rectal and bladder morbidity in prostate cancer patients treated with proton therapy
Subtitle
Multivariate normal tissue complication probability models for rectal and bladder morbidity in prostate cancer patients treated with proton therapy
Proto therapy Time
October 2020
Executive summary
The study included rectum and bladder DVHs, 2D rectal dose maps and relevant patient/treatment characteristics from 1151 prostate cancer cases treated with PT. Prospectively scored Grade 2 late rectal bleeding (n = 156 (15%)) and Grade 3+ GU morbidity (n = 51 (4%)) were entered into a multivariate logistic regression analysis.
This study found that Anticoagulant use and age were the most prominent predictors in the NTCP models. V75Gy of the rectal wall and the bladder was a predictor in the DVH-based models of the rectum and bladder respectively.
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