Subtitle
Long Term Results of a Phase II Study of Adjuvant Proton Radiotherapy for Node-Positive Cancer of the Uterus and Cervix: Proton Radiation for Uterine/Cervical Cancer.
Published in the Red Journal, this study from MGH reported treatment outcomes of 21 patients with node-positive uterine or cervical cancer treated with post-operative proton radiation to the pelvis and para-aortic nodes. With a median follow-up of 60.6 months, acute and late grade 3 GI toxicity were 14 % and 4.7 %, respectively. There were no acute or late grade 3 GU toxicities. There was one late grade 3 lymphedema. The 2- and 5- year PFS were 81 % and 76 %, OS were 86 % and 80 %. QOL increased significantly over time with average increase of 10.7 points from baseline to 5 years. The authors concluded that PBS-PT appears effective in preventing local-regional recurrence in LN+ patients with minimal acute and late toxicity.