This study from Japan reported PBT treatment results for 54 unresectable stage III pancreatic cancer. PBT was performed using the passive method, with a median total dose of 67.5 GyE (range, 50-77 GyE/25-35 fractions). Chemotherapy was used in combination during PBT in 46 patients (85.2%). The median tumor diameter was 36.5 mm (range 15-90 mm). The 1- and 2-year OS was 77.8% and 35.2%, respectively, with a median OS time of 18.2 months, 1- and 2-year local progression free survival rates were 89.7% and 74.5%, respectively. The late effects including peptic ulcer were captured only grade 2+. The late adverse events of grade 3 or higher were not observed. The authors concluded that PBT achieving 67.5 Gy combined with standard chemotherapy showed excellent local control for unresectable LAPC.