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Comparison of local ablative therapies, including radiofrequency ablation, microwave ablation, stereotactic ablative radiotherapy, and particle radiotherapy, for inoperable hepatocellular carcinoma: a systematic review and meta-analysis.

16/04/2023
/ Publications
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Survival

Based on twenty-six primary studies including 1,809 participants, this review reported that microwave ablation (MWA) (p < 0.001) and particle radiotherapy (p <...

Particle beam therapy versus photon radiotherapy for extrahepatic biliary cancer-systemic review and meta-analysis.

16/06/2023
/ Publications

A random-effects meta-analysis was conducted based on 9 original studies with a total 1558 patients (seven photon, n = 1488 patients; two PT, n = 70 patients)...

Ablative radiotherapy for colorectal liver metastases and intrahepatic cholangiocarcinoma.

16/07/2023
/ Publications

For unresectable oligometastases or nonsurgical candidates, SBRT has a growing role with recent randomized phase II trial data indicating a doubling overall...

Proton Beam Therapy versus Radiofrequency Ablation for Patients with Treatment-Naïve Single Hepatocellular Carcinoma: A Propensity Score Analysis.

16/10/2023
/ Publications
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Survival

Ninety-five patients treated with PBT were analyzed compared to 836 patients treated by RFA as controls. The 1-year, 3-year, and 5-year recurrence-free survival...

Proton Therapy in the Management of Pancreatic Cancer.

16/06/2022
/ Publications
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Dosimetry
Reirradiation
Proton Reirradiation

Although proton treatment plans often showed advantages over photon plans in reducing dose to OARs, the clinical implications were yet to be proven. The key...

Dose-escalated proton therapy with elective nodal irradiation and concomitant chemotherapy for unresectable, borderline resectable, or medically inoperable pancreatic cancer: a phase II trial.

16/06/2022
/ Publications
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Dosimetry
Reirradiation

Fifteen patients received proton therapy delivered 40.5 GyRBE in 18 fractions to the gross disease and elective nodal volumes followed by 22.5 GyRBE as a 10...

The Promise of Proton Beam Therapy for Oesophageal Cancer: A Systematic Review of Dosimetric and Clinical Outcomes.

16/08/2021
/ Publications
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Toxicity
Survival

Based on 32 publications, this review reported that significant benefits with PBT suggested by current literature in terms of toxicity reduction, especially in...

Identifying Individualized Risk Profiles for Radiotherapy-Induced Lymphopenia Among Patients With Esophageal Cancer Using Machine Learning.

16/09/2021
/ Publications
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Dosimetry

This study analyzed the retrospective data of 746 patients with esophageal cancer treated with photons (n = 500) and protons (n = 246) to determine the...

The impact of lymphopenia during chemoradiotherapy using photons or protons on the clinical outcomes of esophageal cancer patients.

16/10/2021
/ Publications
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Chemotherapy

This study retrospectively review 69 patients with esophageal cancer treated with XRT (n=15) and PBT (n= 54) and concurrent chemotherapy. The study found that...

A Comparative Analysis of Photon versus Proton Beam Therapy in Neoadjuvant Concurrent Chemoradiotherapy for Intrathoracic Squamous Cell Carcinoma of the Esophagus at a Single Institute.

16/04/2022
/ Publications
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Chemotherapy

This study compared the results of 31 patients with locally advanced esophageal cancer treated with neoadjuvant chemoradiotherapy to a median total dose 41.4 Gy...