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The Potential Role of Intensity-Modulated Proton Therapy in Hepatic Carcinoma in Mitigating the Risk of Dose De-Escalation

10/12/2020
/ Publications
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VMAT
IMPT

A cohort of 30 patients was retrospectively selected as "at-risk" of dose de-escalation due to the proximity of the target volumes to dose-limiting healthy...

Efficacy and feasibility of proton beam radiotherapy using the simultaneous integrated boost technique for locally advanced pancreatic cancer

10/12/2020
/ Publications

A study by the NCC, Korea group analyzed 81 patients with locally advanced pancreatic cancer (LAPC), treated with PBT simultaneous integrated boost (SIB)...

Proton therapy for thoracic malignancies: a review of oncologic outcomes

01/01/2021
/ Publications

This review examined PBT physical properties, treatment techniques including the recent advances in planning and delivery, and clinical outcomes for each of the...

Outcomes following limited-volume proton therapy for multifocal spinal myxopapillary ependymoma

10/11/2020
/ Publications
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Toxicity

A study by the Jacksonville group reported the disease control and toxicity in 12 pediatric patients with multifocal spinal myxopapillary ependymoma (MPE)...

FLASH Investigations Using Protons: Design of Delivery System, Preclinical Setup and Confirmation of FLASH Effect with Protons in AnimalSystems.

01/12/2020
/ Publications
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FLASH Therapy

Extremely high-dose-rate irradiation, referred to as FLASH, has been shown to be less damaging to normal tissues than the same dose administrated at...

Secondary Malignancy Risk Following Proton vs. X-ray Treatment of Mediastinal Malignant Lymphoma: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk.

10/10/2020
/ Publications
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IMRT
Secondary cancer

This study estimated secondary cancer risks for 23 mediastinal lymphoma patients treated with PBT in comparison with helical photon IMRT re-plans. PBT was...

Proton pencil beam scanning reduces secondary cancer risk in breast cancer patients with internal mammary chain involvement compared to photon radiotherapy.

01/10/2020
/ Publications
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Secondary cancer

This study compared tangential 3D-CRT and VMAT to PBS proton therapy in secondary cancer risk (SCR) for the lungs and for contralateral breast. PBS PT was...

Hypofractionated proton beam radiotherapy in patients with unresectable liver tumors: multi-institutional prospective results from the Proton Collaborative Group.

10/11/2020
/ Publications
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Hypofractionation

This study analyzed the data of 63 patients with liver tumors treated with PBT. Hypofractionated PBT resulted in excellent local control, sparing of the...

Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: a randomized phase trial.

01/10/2020
/ Publications
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Toxicity

This randomized study compared PBT and radiofrequency ablation (RFA) for patients with recurrent/residual HCC. The local progression free survival values of PBT...

Image-Guided Hypofractionated Proton Therapy in Early-Stage Non-Small Cell Lung Cancer: A Phase 2 Study.

10/11/2020
/ Publications
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Hypofractionation
Survival

22 patients with T1 to T2 N0M0 NSCLC received image-guided hypofractionated PBT to a total dose 48 GyRBE in 4 fractions for peripheral lesions and 60 GyRBE in...