Subtitle
Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy.
Subtitle
Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy.
Proto therapy Time
June 2021
Executive summary
Seventy-seven patients with nonmetastatic NPC received IMPT (n=28) or IMRT(n=49). With a median follow-up time of 30.3 months, IMPT was associated with lower likelihood of grade 2 or higher acute AEs compared with IMRT (P = .01). Only 1 case (3.8%) of a chronic grade 3 or higher AE occurred in the IMPT group compared with 8 cases (16.3%) in the IMRT group (P = .15). Propensity score matching of 48 patients (24 IMPT vs 24 IMRT) showed similar PFS in both groups. Two-year LRFS was 100% in the IMPT group and 86.2% in the IMRT group (P = .08). Three-year OS was 100% in the IMPT group and 94.1% in the IMRT group (P = .42).
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