This study reported toxicities of 43 children with medulloblastoma treated with PBS-PT. The most common (>30% of patients) acute toxicities were radiation dermatitis (n = 28, 65.1%), pharyngeal mucositis (22, 51.2%), nausea (19, 44.1%), non-preexisting alopecia (17 out of 18 without preexisting alopecia, 94.4%), anorexia (16, 37.2%), and fatigue (15, 34.9%). Seven patients (16.3%) developed hearing impairment at follow-up audiometry, in five cases bilateral, in two cases monoliteral at a median time of 9 months after PT.