Published in the Journal of Clinical Oncology, this multi-center study compared the intellectual trajectories between pediatric patients treated for medulloblastoma with PRT versus those treated with XRT. This study examined intelligence data from 79 patients (37 PRT, 42 XRT) and reported that the PRT group exhibited superior long-term outcomes in global intelligence quotient (IQ), perceptual reasoning, and working memory compared with the XRT group (all P < .05).

The authors concluded that PRT was associated with more favorable intellectual outcomes in most domains compared with XRT, and this study provides the strongest evidence to date of an intellectual sparing advantage with PRT in the treatment of pediatric medulloblastoma.