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Proton beam therapy for craniopharyngioma: a systematic review and meta-analysis

November 2024
Executive summary

This review included 8 primary studies comprising 393 patients with craniopharyngioma treated with PBT to a median total dose of 54 GyRBE, 1.8 Gy per fraction. At 3 and 5 years, local control rates were 99% and 93%; overall survival rates were both 100%. The incidence of acute and late toxicities was mainly grade 1-2.

The authors concluded that PBT for craniopharyngiomas, especially in children and adolescents, has shown encouraging survival results and appears to have no current evidence of superiority over conventional photon RT.

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