This study by the Jacksonville group reported treatment outcomes of eight patients with pediatric nonmetastatic spinal low-grade glioma (LGG-S) treated with PT. All patients underwent attempted resection and developed recurrence/progression prior to referral for PT. Median follow up was 7.8 years. The 10-year estimates for local control, freedom from distant metastases, freedom from progression, and OS were 85, 88, 73, and 55%, respectively. No pulmonary, gastrointestinal, or musculoskeletal toxicities were observed during or after PT. The authors concluded that PT for pediatric LGG-S offers long-term disease control with limited toxicity, and that PT should be considered among first-line therapy in children with nonmetastatic, unresectable LGG-S.