A review examined the reported data of hypofractionation with PBT. Over 50 published manuscripts were included for analysis. The most common treatment regions reported were prostate, lung and liver, making over 70% of the reported results. Hypofrationated PBT has been reported also for intracranial, breast and retroperitoneal sarcoma. 90% data was published since 2010, among which 36 reports published in the past 5 years making over 60% of the total reported data. This shows a significant and growing interest in the field of hypofractionation with PBT.