Published in Seminar Radiation Oncology, this review article evaluated clinical data up-to-date on proton reirradiation for local and regional recurrence. As photon reirradiation can be associated with considerable risks of high grade acute and late toxicities, protons offer significant advantages for reirradiation.

The renowned experts in the fields of lung cancer, head and neck malignancies, and pelvic malignancies provided assessment on proton reirradiation. In conclusion, this review article pointed out that in select patients, PT is often the best modality for delivering reirradiation. IMPT offers increased dose conformality and even further advantages over photon therapy in the setting of reirradiation. IMPT and volumetric image-guidance with proton therapy makes reirradiation dose escalation more feasible.