Subtitle
Proton beam therapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus.
Subtitle
Proton beam therapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus.
Proto therapy Time
November 2019
Executive summary
Hepatocellular carcinoma (HCC) with inferior vena cava tumor thrombus (IVCTT) is rare and regarded as an advanced disease stage with a poor prognosis. This study from Japan reported outcomes of 21 HCC patients with IVCTT treated with proton therapy. For acute toxicities, dermatitis of grade 1-2 was observed in all patients, but no grade 3 or higher late toxicity events were encountered.
The overall survival (OS) rates for all patients were 62%, 33%, and 19% at 1, 2, and 3 years, respectively. No local recurrences for the treated lesions, including IVCTT, were observed. The authors concluded that PBT is safe and effective and is an important treatment option for HCC patients with IVCTT.
Key content topics
Top cancer treatments
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