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Patterns of failure following proton beam therapy for head and neck rhabdomyosarcoma (RMS).

February 2019
Executive summary

A MD Anderson study published in the Green Journal reported on the patterns of failure following proton beam therapy (PBT) for pediatric H&N RMS. 46 patients were analyzed. With median follow-up of 3.9 years, five-year overall survival was 76%, and five-year progression-free survival was 57%. Seventeen patients (37%) experienced relapse, including 7 with local failure (LF). Five-year local control (LC) was 84%.

Tumor size greater than 5 cm predicted increased risk of LF, intracranial extension (ICE) and delayed RT delivery after week 4 of chemotherapy predicted increased risk of relapse. This study concluded that PBT confers excellent LC, and a favorable late toxicity profile as compared with prior photon RT data. This study also raised concerns regarding excess failures among patients with ICE.

Key content topics
Chemotherapy
Top cancer treatments
Pediatric
Head and neck

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