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Meta-analysis of the incidence and patterns of second neoplasms (SNs) after photon craniospinal irradiation (CSI) in children with medulloblastoma (MB).

April 2018
Executive summary

This meta-analysis reported that the 10-year cumulative incidence was 6.1% for all SNs, including 3.1% for SBNs (benign) and 3.7% for SMNs (malignant), with a majority in areas of exit RT dose.

Studies are needed to determine whether the use of proton therapy, which has no exit RT dose, is associated with a lower incidence of SNs.

Top cancer treatments
Pediatric
Brain and CNS

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