Executive summary

This study reported the efficacy and safety of image-guided proton therapy (IGPT) for elderly (≥80 years old) hepatocellular carcinoma (HCC) patients. Seventy-one elderly HCC patients were treated using IGPT to a total dose of 66 GyRBE in 10 fractions and 72.6 GyRBE in 22 fractions for central lesions. With the median follow-up 33 months, the 2-year OS and LC were 76% and 88%. No grade 2 or higher radiation-induced liver disease was observed, and only 1 patient developed grade 3 dermatitis. 

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