This study compared differential effects of enucleation and PBR on 115 uveal melanoma patients based on the patient-reported outcomes. This study found that PBR patients reported greater impairments of central and peripheral vision (P = 0.009) and reading difficulties (P = 0.002) over 24 months. Patients treated by enucleation experienced greater functional problems at 6 months, which abated at 12 and 24 months.

This study pointed out that it is important that patients and clinicians consider long-standing difficulties of visual impairment associated with PBR and temporary 6-month difficulties in activities related to depth perception associated with enucleation.