A review article published in the Green Journal. Having analyzed the available data of PBT for paediatric cancers of the central nervous system (CNS), this study found that PBT provided survival and tumour control outcomes comparable, and frequently superior, to photon therapy. The use of protons was shown to decrease the incidence of severe acute and late toxicities, including reduced severity of endocrine, neurological, IQ and QoL deficits.

This review makes concludsion that current evidence supports PBT effectiveness and potential benefits in reducing the incidence of late-onset toxicities and second malignancies. For stronger evidence, it is highly desired for future studies to improve current reporting by (1) highlighting the paediatric patient cohort's outcome (in mixed patient groups), (2) reporting the follow-up time, (3) clearly indicating the toxicity criteria used in their evaluation, and (4) identifying the risk group.