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Clinical outcomes and factors involved in the local control of proton beam therapy for oligometastatic liver tumors in patients with colorectal cancer.

01/03/2024
/ Publications

This study reported outcomes of 41 patients with colorectal cancer liver metastases (63 lesions) treated with PBT to a total dose of 72.6 GyRBE in 22 fractions...

Gastrointestinal bleeding/ulcer among paediatric cancer patients after proton beam therapy.

13/06/2023
/ Publications
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Reirradiation
Chemotherapy

This study analyzed 124 patients who underwent proton therapy with gastrointestinal tract involved in the irradiated field. The study reported gastrointestinal...

Image-Guided Proton Therapy for Elderly Patients with Hepatocellular Carcinoma: High Local Control and Quality of Life Preservation.

16/12/2021
/ Publications
/
Quality of life

This study reported the efficacy and safety of image-guided proton therapy (IGPT) for elderly (≥80 years old) hepatocellular carcinoma (HCC) patients. Seventy...

Long-term clinical outcomes of patients receiving proton beam therapy for caudate lobe hepatocellular carcinoma.

16/07/2021
/ Publications
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Clinical Trial

Thirty patients with caudate lobe HCC were treated to a total doses of 55 to 77 (median 72.6) GyRBE. The median follow-up period was 37.5 months. The OS rates...

A phase II trial of hypofractionated high-dose proton beam therapy for unresectable liver metastases.

16/11/2022
/ Publications
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Dosimetry
Toxicity

This study analyzed 46 patients with 49 liver metastases treated by PBT to a total dose of 60 GyRBE in 5 fractions (BED 132 GyE) or 70 GyRBE in 10 (BED 119 GyE)...

Comparison of local ablative therapies, including radiofrequency ablation, microwave ablation, stereotactic ablative radiotherapy, and particle radiotherapy, for inoperable hepatocellular carcinoma: a systematic review and meta-analysis.

16/04/2023
/ Publications
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Survival

Based on twenty-six primary studies including 1,809 participants, this review reported that microwave ablation (MWA) (p < 0.001) and particle radiotherapy (p <...

Particle beam therapy versus photon radiotherapy for extrahepatic biliary cancer-systemic review and meta-analysis.

16/06/2023
/ Publications

A random-effects meta-analysis was conducted based on 9 original studies with a total 1558 patients (seven photon, n = 1488 patients; two PT, n = 70 patients)...

Ablative radiotherapy for colorectal liver metastases and intrahepatic cholangiocarcinoma.

16/07/2023
/ Publications

For unresectable oligometastases or nonsurgical candidates, SBRT has a growing role with recent randomized phase II trial data indicating a doubling overall...

Proton Beam Therapy versus Radiofrequency Ablation for Patients with Treatment-Naïve Single Hepatocellular Carcinoma: A Propensity Score Analysis.

16/10/2023
/ Publications
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Survival

Ninety-five patients treated with PBT were analyzed compared to 836 patients treated by RFA as controls. The 1-year, 3-year, and 5-year recurrence-free survival...

Proton Therapy in the Management of Pancreatic Cancer.

16/06/2022
/ Publications
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Dosimetry
Reirradiation
Proton Reirradiation

Although proton treatment plans often showed advantages over photon plans in reducing dose to OARs, the clinical implications were yet to be proven. The key...