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The Potential Role of Intensity-Modulated Proton Therapy in Hepatic Carcinoma in Mitigating the Risk of Dose De-Escalation

10/12/2020
/ Publications
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VMAT
IMPT

A cohort of 30 patients was retrospectively selected as "at-risk" of dose de-escalation due to the proximity of the target volumes to dose-limiting healthy...

Efficacy and feasibility of proton beam radiotherapy using the simultaneous integrated boost technique for locally advanced pancreatic cancer

10/12/2020
/ Publications

A study by the NCC, Korea group analyzed 81 patients with locally advanced pancreatic cancer (LAPC), treated with PBT simultaneous integrated boost (SIB)...

Secondary Malignancy Risk Following Proton vs. X-ray Treatment of Mediastinal Malignant Lymphoma: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk.

10/10/2020
/ Publications
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IMRT
Secondary cancer

This study estimated secondary cancer risks for 23 mediastinal lymphoma patients treated with PBT in comparison with helical photon IMRT re-plans. PBT was...

Hypofractionated proton beam radiotherapy in patients with unresectable liver tumors: multi-institutional prospective results from the Proton Collaborative Group.

10/11/2020
/ Publications
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Hypofractionation

This study analyzed the data of 63 patients with liver tumors treated with PBT. Hypofractionated PBT resulted in excellent local control, sparing of the...

Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: a randomized phase trial.

01/10/2020
/ Publications
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Toxicity

This randomized study compared PBT and radiofrequency ablation (RFA) for patients with recurrent/residual HCC. The local progression free survival values of PBT...

Radiation-Associated Lymphopenia and Outcomes of Patients with Unresectable HCC Treated with Radiotherapy.

04/03/2021
/ Publications

Lymphopenia caused by radiotherapy is associated with a poor prognosis. This study reviewed 143 HCC patients treated with photon (n=103 (72%)) and proton (n=40...

Abscopal Effect Followiing PBRT in a Patient With Inoperable Metastatic Retroperitoneal Sarcoma.

09/09/2019
/ Publications
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Immunotherapy

The first case report of an abscopal effect in a patient of retroperitoneal sarcomas (RPS) treated with proton therapy. A 67 year-old female with inoperable...

Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma (B/P-RMS).

07/08/2019
/ Publications
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Toxicity

This study reported outcomes of 19 patients of B/P-RMS treated with PBT. With a median follow-up of 66.2 months, 5-year overall survival (OS) and progression...

Optimizing neoadjuvant radiotherapy for resectable and borderline resectable pancreatic cancer using protons.

07/07/2019
/ Publications

Approximately 25% of patients diagnosed with pancreatic cancer present with non-metastatic resectable or borderline resectable disease. Preoperative...

Proton beam therapy versus stereotactic body radiotherapy for hepatocellular carcinoma: practice patterns, outcomes, and the effect of biologically effective dose escalation.

07/10/2019
/ Publications

With the National Cancer Database for T1-2N0 HCC patients receiving PBT or SBRT, a total of 71 patients received PBT and 918 patients received SBRT were...