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Proton FLASH radiotherapy ameliorates radiation-induced salivary gland dysfunction and oral mucositis and increases survival in a mouse model of head and neck cancer.

06/05/2024
/ Publications
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FLASH Therapy
Reirradiation
Toxicity
Survival

Published by the Upenn group, this study reported reduced xerostomia with FLASH proton compared to standard proton therapy in mice. The head and neck area of...

Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy

14/04/2021
/ Publications
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Survival

This study reported clinical outcomes of 68 patients with major salivary gland tumors including the parotid gland (75.0%) and adenoid cystic carcinoma (22.1%)...

Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy.

14/06/2021
/ Publications
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Toxicity
Survival
IMPT

Seventy-seven patients with nonmetastatic NPC received IMPT (n=28) or IMRT(n=49). With a median follow-up time of 30.3 months, IMPT was associated with lower...

Proton Therapy for HPV-Associated Oropharyngeal Cancers of the Head and Neck: a De-Intensification Strategy.

14/06/2021
/ Publications
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IMPT
IMRT
Toxicity

This review suggested that IMPT could de-intensifies treatment through dose de-escalation to normal tissues without compromising dose to the primary tumor and...

A comparison of acute toxicities and patient-reported outcomes between intensity-modulated proton therapy and volumetric-modulated arc therapy after ipsilateral radiation for head and neck cancers.

14/02/2022
/ Publications
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IMPT
VMAT
Toxicity
ARC therapy

A cohort of tonsil and salivary gland cancer patients who received ipsilateral curative-intent radiotherapy delivered by IMPT or VMAT were reviewed. This study...

Proton Therapy for Squamous Cell Carcinoma of the Head and Neck: Early Clinical Experience and Current Challenges.

14/05/2022
/ Publications
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IMRT
Reirradiation

A significant reduction of toxicities, such as xerostomia, dysgeusia and feeding tube placement has been reported in studies of definitive PT for NPSCC...

Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Oropharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy.

14/11/2022
/ Publications
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IMPT
IMRT
Toxicity
Survival

Among the 292 patients with nonmetastatic oropharyngeal cancer of which 272 [93%] were HPV–positive tumors, 58 patients (20%) were treated with IMPT and 234 (80...

Toxicity with proton therapy for oral and/or oropharyngeal cancers: A scoping review.

14/08/2023
/ Publications
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Toxicity

This review included 18 primary studies for analysis focusing on acute toxicities including dysphagia, radiation dermatitis, oral mucositis, dysgeusia and...

Advances in Proton Therapy for the Management of Head and Neck Tumors.

14/07/2023
/ Publications
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Toxicity

A review article summarized the advances of PBRT as compared to photon-based RT. Clinical evidence has demonstrated promising results of PBRT in the treatment...

Long-term outcomes of modern multidisciplinary management of sinonasal cancers: The M. D. Anderson experience.

14/07/2023
/ Publications
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Toxicity
IMRT

This is study retrospectively analyzed 311 patients with sinonasal tumors treated with IMRT or PT. With median follow-up of 75 months, this study reported 10...