Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC): An open label, randomized, stratified, phase II trial
29/10/2024
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Publications
. Published in the Green Journal, this study by the Heidelberg group reported treatment outcomes of 82 patients with inoperable or incompletely resected sacral...
Effectiveness and Safety of Carbon Ion Radiotherapy in Solid Tumors: A Systematic Review and Meta-Analysis.
30/10/2024
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Publications
This systematic review and meta-analysis included 34 comparative studies and evaluated the effectiveness of carbon ion radiotherapy (CIRT) in patients with...
Particle Therapy in Adult Patients with Pelvic Ewing Sarcoma-Tumor and Treatment Characteristics and Early Clinical Outcomes.
16/01/2023
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Publications
This study reported early outcomes of 21 adult pelvic Ewing sarcoma treated with PT (n=18 primary disease) to a total dose of 45-60 GyRBE and with carbon ion (n...
A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-chondrosarcoma 2024.
06/05/2024
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Publications
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Survival
Based on 21 original studies, this meta-analysis reported a significant association of PT with a superior 5-year OS rate compared to three-dimensional conformal...
The Use of Proton and Carbon Ion Radiation Therapy for Sarcomas.
06/05/2024
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Publications
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Reirradiation
. A review article by the MGH group summarized clinical data of particle therapy for chordoma, chondrosarcoma, Ewing sarcoma, osteosarcoma, retroperitoneal...
Proton beam therapy for clival chordoma: Optimising rare cancer treatments in Australia.
06/05/2024
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Publications
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Quality assurance
This review evaluated clinical evidence of surgery, photon-based radiotherapy and proton therapy for clival chordoma. The authors stated that contemporaneous...
FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma?
06/05/2024
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Publications
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FLASH Therapy
Dosimetry
Toxicity
A review article by the Upenn group summarized the preclinical and clinical evidence for the FLASH effect and discussed the potential clinical significance for...
Vision loss following high-dose proton-based radiotherapy for skull-base chordoma and chondrosarcoma
14/05/2021
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Publications
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Dosimetry
This study included148 chordoma and chondrosarcoma patients and 283 individual eyes with functional vision at baseline who received a minimum 30GyRBE to 0.1cm3...
Particle Radiotherapy for Skull Base Chondrosarcoma: A Clinical Series from Italian National Center for Oncological Hadrontherapy.
14/09/2021
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Publications
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Toxicity
This study reported outcomes of 48 patients with skull base chondrosarcoma who underwent particle therapy (67% PT, 33% CIRT). With a median follow-up of 38...
Definitive high-dose, proton-based radiation for unresected mobile spine and sacral chordomas.
14/06/2022
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Publications
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Survival
Dosimetry
Sixty-seven patients with unresected spinal chordomas treated with PBT were evaluated. With a median follow-up of 56.2 months, 5- and 8-year OS were 83.5 % and...
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