Image-Guided Proton Therapy for Elderly Patients with Hepatocellular Carcinoma: High Local Control and Quality of Life Preservation.
16/12/2021
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Publications
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Quality of life
This study reported the efficacy and safety of image-guided proton therapy (IGPT) for elderly (≥80 years old) hepatocellular carcinoma (HCC) patients. Seventy...
Long-term clinical outcomes of patients receiving proton beam therapy for caudate lobe hepatocellular carcinoma.
16/07/2021
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Publications
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Clinical Trial
Thirty patients with caudate lobe HCC were treated to a total doses of 55 to 77 (median 72.6) GyRBE. The median follow-up period was 37.5 months. The OS rates...
A phase II trial of hypofractionated high-dose proton beam therapy for unresectable liver metastases.
16/11/2022
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Publications
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Dosimetry
Toxicity
This study analyzed 46 patients with 49 liver metastases treated by PBT to a total dose of 60 GyRBE in 5 fractions (BED 132 GyE) or 70 GyRBE in 10 (BED 119 GyE)...
Comparison of local ablative therapies, including radiofrequency ablation, microwave ablation, stereotactic ablative radiotherapy, and particle radiotherapy, for inoperable hepatocellular carcinoma: a systematic review and meta-analysis.
16/04/2023
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Publications
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Survival
Based on twenty-six primary studies including 1,809 participants, this review reported that microwave ablation (MWA) (p < 0.001) and particle radiotherapy (p <...
Particle beam therapy versus photon radiotherapy for extrahepatic biliary cancer-systemic review and meta-analysis.
16/06/2023
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Publications
A random-effects meta-analysis was conducted based on 9 original studies with a total 1558 patients (seven photon, n = 1488 patients; two PT, n = 70 patients)...
Ablative radiotherapy for colorectal liver metastases and intrahepatic cholangiocarcinoma.
16/07/2023
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Publications
For unresectable oligometastases or nonsurgical candidates, SBRT has a growing role with recent randomized phase II trial data indicating a doubling overall...
Proton Beam Therapy versus Radiofrequency Ablation for Patients with Treatment-Naïve Single Hepatocellular Carcinoma: A Propensity Score Analysis.
16/10/2023
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Publications
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Survival
Ninety-five patients treated with PBT were analyzed compared to 836 patients treated by RFA as controls. The 1-year, 3-year, and 5-year recurrence-free survival...
Proton Therapy in the Management of Pancreatic Cancer.
16/06/2022
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Publications
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Dosimetry
Reirradiation
Proton Reirradiation
Although proton treatment plans often showed advantages over photon plans in reducing dose to OARs, the clinical implications were yet to be proven. The key...
Dose-escalated proton therapy with elective nodal irradiation and concomitant chemotherapy for unresectable, borderline resectable, or medically inoperable pancreatic cancer: a phase II trial.
16/06/2022
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Publications
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Dosimetry
Reirradiation
Fifteen patients received proton therapy delivered 40.5 GyRBE in 18 fractions to the gross disease and elective nodal volumes followed by 22.5 GyRBE as a 10...
The Promise of Proton Beam Therapy for Oesophageal Cancer: A Systematic Review of Dosimetric and Clinical Outcomes.
16/08/2021
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Publications
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Toxicity
Survival
Based on 32 publications, this review reported that significant benefits with PBT suggested by current literature in terms of toxicity reduction, especially in...
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