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Hypofractionation in Proton Therapy: radiobiological bases and clinical applications

19/04/2023
/ Webinar
/
Hypofractionation

The use of hypofractionated schedules in proton therapy is rapidly increasing. Their application has several advantages, including the reduction of overall...

Proton Beam Therapy in the Reirradiation Setting of Brain and Base of Skull Tumour Recurrences.

05/09/2023
/ Publications

This systematic review included 12 original studies of PBT reirradiation for brain/base of skull tumor recurrences. The available clinical data showed that PBT...

Proton beam radiation therapy for vestibular schwannomas – tumor control and hearing preservation rates: a systematic review and meta-analysis.

05/09/2023
/ Publications

This meta-analysis included 8 primary studies with a total number of 587 patients with vestibular schwannomas treated with proton radiation. Overall rate of...

Cochlear-optimized treatment planning in photon and proton radiosurgery for vestibular schwannoma patients.

23/11/2023
/ Publications

This study compared photon radiosurgery plans and IMPT plans to the clinically delivered photon treatment plans of 24 vestibular schwannoma patients to...

Hypofractionated proton therapy for benign tumors of the central nervous system: A systematic review of the literature.

23/11/2023
/ Publications

This systematic review summarized results of the literature in the setting of patients treated with hypofractionated PT for benign lesions of the central...

High-dose proton beam therapy versus conventional fractionated radiation therapy for newly diagnosed glioblastoma: a propensity score matching analysis.

28/02/2024
/ Publications

This study compared the survival outcomes and toxicities of high-dose PBT of 96.6 GyRBE and CRT of 60 Gy using propensity score-matched treatment cohorts. From...

Long-term outcomes of fractionated proton beam therapy for benign or radiographic intracranial meningioma.

28/02/2024
/ Publications

This study reported outcomes of 59 (64 lesions) patients with benign intracranial meningioma treated with PBT to a median total dose of 50.4 GyRBE at 1.8 GyRBE...

Outcomes of Patients Treated in the UK Proton Overseas Programme: Central Nervous System Group.

01/03/2024
/ Publications

This report presented the outcomes of patients treated in in the UK proton overseas program (POP). 830 patients with central nervous system (CNS), base of skull...

Efficacy and toxicity of photon, proton, and carbon ion radiotherapy in the treatment of intracranial solitary fibrous tumor/hemangiopericytoma.

06/05/2024
/ Publications
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Toxicity
Proton Reirradiation

This study from the Heidelberg group reported results of 34 patients (12 patients of recurrence) with CNS solitary fibrous tumors (SFT) treated with photon...

Systematic review and pooled analysis of the impact of treatment-induced lymphopenia on survival of glioblastoma patients.

06/05/2024
/ Publications
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Survival

This review included 10 studies representing 1,718 patients. A pooled analysis was performed to evaluate the relationship between lymphopenia and overall...