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Clinical Outcomes of Pencil Beam Scanning Proton Therapy in Locally Advanced Non-Small Cell Lung Cancer: Propensity Score Analysis.

14/07/2021
/ Publications
/
IMRT
Pencil Beam Scanning - PBS

For a cohort of 219 patients with stage III NSCLC who received definitive concurrent chemoradiotherapy, 25 patients (11.4%) underwent PBSPT and 194 patients (88...

Dosimetry, Efficacy, Safety, and Cost-Effectiveness of Proton Therapy for Non-Small Cell Lung Cancer.

14/09/2021
/ Publications
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Toxicity
IMRT

In the early-stage NSCLC setting, all of the studies had a small sample size and were single-arm without direct comparison. Proton therapy was promising for...

Exposure of the heart in lung cancer radiation therapy: A systematic review of heart doses published during 2013 to 2020.

01/07/2022
/ Publications
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Dosimetry
IMRT
Motion Management

Data of 140 dosimetry studies was analyzed. In the 105 non-SABR studies, the average MHD was similar between IMRT and 3DCRT (10.9 Gy versus 10.6 Gy) and lower...

Proton beam therapy in rectal cancer: A systematic review and meta-analysis.

16/09/2021
/ Publications
/
IMRT
Dosimetry

This review article examined eight original studies with a total of 127 patients. There was significantly less irradiated small bowel with PBT compared to 3DCRT...

Hematologic Toxicity Comparison of Intensity Modulated Proton Therapy and Intensity Modulated Radiation Therapy in Anal Cancer Patients.

16/06/2022
/ Publications
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IMRT
IMPT
Dosimetry

This study compared hematologic toxicity in 41 anal cancer patients treated with IMPT (n=14) or IMRT (n=27). This study found all pelvic bone marrow dose...

A Pooled Toxicity Analysis of Moderately Hypofractionated Proton Beam Therapy and Intensity-Modulated Radiation Therapy in Early Stage Prostate Cancer Patients.

16/06/2021
/ Publications
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Hypofractionation
Toxicity
IMRT

This multi-institutional study compared late toxicity profiles of a total of 1850 patients, including 1282 IMRT and 568 PBT. Overall toxicity rates were low...

Secondary Malignancy Risk Following Proton vs. X-ray Radiotherapy of Thymic Epithelial Tumors: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk.

16/05/2022
/ Publications
/
IMRT
Secondary cancer

A modeling study demonstrated significant reduction in secondary malignancy (SM) with the use of PBS relative to both 3DCRT and IMRT for all independent...

Optimal allocation of proton therapy slots in combined proton-photon radiotherapy.

16/09/2021
/ Publications
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IMRT
IMPT

Using a cohort of 45 head-and-neck cancer patients for which IMRT and IMPT plans were previously created, in combination with NTCP models for xerostomia and...