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Top cancer treatments

The role of combined ion-beam radiotherapy (CIBRT) with protons and carbon ions in a multimodal treatment strategy of inoperable osteosarcoma.

16/06/2021
/ Publications
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Toxicity

This study reported the outcomes of 20 patients with primary (N=18), metastatic (N=3), or recurrent (N=2) inoperable pelvic (70%) or craniofacial (30%)...

Proton Therapy for Primary Bone Malignancy of the Pelvic and Lumbar Region - Data From the Prospective Registries ProReg and KiProReg.

16/02/2022
/ Publications
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Toxicity

Eighty-one patients with primary bone malignancy, including Ewing’s sarcoma (58%), chondrosarcoma (7.4%), chordoma (24.7%), osteosarcoma (7.4%), and...

Secondary Malignancy Risk Following Proton vs. X-ray Radiotherapy of Thymic Epithelial Tumors: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk.

16/05/2022
/ Publications
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IMRT
Secondary cancer

A modeling study demonstrated significant reduction in secondary malignancy (SM) with the use of PBS relative to both 3DCRT and IMRT for all independent...

Individualized quality of life benefit and cost-effectiveness estimates of proton therapy for patients with oropharyngeal cancer.

16/01/2021
/ Publications
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Quality of life
Cost management
Reirradiation

Proton therapy was more likely to be cost-effective for patients with p16-positive tumors ($234,201/QALY), compared to p16-negative tumors ($516,297/QALY). For...

A Systematic Review of the Economic Burden of Proton Therapy in Head and Neck Cancer.

16/11/2023
/ Publications
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Cost management

Based on 10 original studies, this systematic review reported that PBT can be cost-effective for HPV-associated tumors and for younger patients. A clinically...

Development of advanced preselection tools to reduce redundant plan comparisons in model-based selection of head and neck cancer patients for proton therapy.

16/07/2021
/ Publications
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VMAT
IMPT

Using data from VMAT plans and volumetric data from delineated targets and OARs, the researchers developed the advanced preselection tools that prevented labor...

Identification of patient benefit from proton beam therapy in brain tumour patients based on dosimetric and NTCP analyses.

16/07/2021
/ Publications
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VMAT

This study used data of 92 patients treated with protons to create VMAT plans for comparison. NTCP differences were calculated for 11 models predicting brain...

Optimal allocation of proton therapy slots in combined proton-photon radiotherapy.

16/09/2021
/ Publications
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IMRT
IMPT

Using a cohort of 45 head-and-neck cancer patients for which IMRT and IMPT plans were previously created, in combination with NTCP models for xerostomia and...

Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy.

16/03/2021
/ Publications
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Immunotherapy

A review article discussed the possible synergy of radiotherapy and immunotherapy, and the theoretical basis that charged particle RT (PRT) may enhance tumor...

Young Adult Populations Face Yet Another Barrier to Care with Insurers: Limited Access to Proton Therapy.

16/08/2021
/ Publications
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Toxicity
Secondary cancer

Young adult patients (n = 68/143, 48%) were significantly less likely to receive initial approval compared with pediatric patients (n = 139/141; 99%) (P < .001)...