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Patient Reported Outcomes Following Proton Pencil Beam Scanning vs. Passive Scatter/Uniform Scanning for Localized Prostate Cancer: Secondary Analysis of PCG 001-09.

03/03/2020
/ Publications
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Pencil Beam Scanning - PBS

This study evaluated PROs with the Expanded Prostate Cancer Index Composite (EPIC) instrument for men with localized PC enrolled in PCG 001-09 (NCT01255748)...

End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer.

03/03/2020
/ Publications

Published in the Red Journal, this MGH study looked into the possible causes to the high rate of rib fracture that reported in the recent MGH prospective trial...

Acute Toxicities After Proton Beam Therapy Following Breast-Conserving Surgery for Breast Cancer: Multi-institutional Prospective PCG Registry Analysis. This is the report of the prospective multi-institutional Proton Collaborative Group registry study.

03/04/2020
/ Publications

82 patients received PBT and their adverse events (AEs) were recorded prospectively at each institution. Median follow-up was 8.1 months. Median dose was 50.4...

Perspectives on the model-based approach to proton therapy trials: A retrospective study of a lung cancer randomized trial.

03/03/2020
/ Publications
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Model-based approach

Published in the Green Journal, this study was to assess whether a model-based approach applied retrospectively to a completed randomized controlled trial (RCT)...

Hypofractionated Proton Therapy With Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Phase I Trial From the University of Florida and Proton Collaborative Group.

03/04/2020
/ Publications
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Hypofractionation
Chemotherapy

Published in the Red Journal, this study reported the safety data from the first multicenter phase I trial investigating the use of hypofractionated proton...

NTCP Models for Severe Radiation Induced Dermatitis After IMRT or Proton Therapy for Thoracic Cancer Patients.

30/04/2020
/ Publications

Lyman-Kutcher-Burman normal tissue complication probability modeling for radiation-induced esophagitis in non-small cell lung cancer patients receiving proton...

Combining Immunotherapy with Radiation Therapy in Non-Small Cell Lung Cancer.

02/03/2020
/ Publications
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Immunotherapy

As immunotherapy, especially the immune checkpoint inhibitors have recently been demonstrated to improve survival in metastatic and locally advanced non-small...

Proton Reirradiation: Expert Recommendations for Reducing Toxicities and Offering New Chances of Cure in Patients With Challenging Recurrence Malignancies.

05/07/2020
/ Publications
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Toxicity
Reirradiation
IMPT

Published in Seminar Radiation Oncology, this review article evaluated clinical data up-to-date on proton reirradiation for local and regional recurrence. As...

Scanning Beam Proton Therapy (SPT) Versus Photon IMRT for Stage III Lung Cancer: Comparison of Dosimetry, Toxicity, and Outcomes.

05/03/2020
/ Publications
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IMRT

This study reviewed dosimetric data and clinical outcomes of 64 stage III lung cancer patients treated with SPT (34) + IMRT (30). Mean dose to lung, heart, and...

Proton Beam Therapy Is a Safe and Effective Treatment in Elderly Patients With Esophageal Squamous Cell Carcinoma (ESCC).

05/06/2020
/ Publications
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Toxicity
Survival

This study from Japan reported results of 54 esophageal cancer patients who are over 75 years old treated with PBT. 38 inoperable patients (70.4%) and 16...