Subtitle
Proton Therapy for Squamous Cell Carcinoma of the Head and Neck: Early Clinical Experience and Current Challenges.
A significant reduction of toxicities, such as xerostomia, dysgeusia and feeding tube placement has been reported in studies of definitive PT for NPSCC (nasopharynx) and OPSCC (oropharynx). However an increased radiation-induced dermatitis has also reported in the PT groups. In the setting of dose (de-) escalation, adjuvant treatment and reirradiation, there is a paucity of data regarding the benefits of PT. Overall, this review suggests that PT is a promising treatment option for HNSCC, however prospective well-designed investigations comparing PT to IMRT are necessary.