A review of latest development on lymphomas management with proton therapy, including details of proton physic properties, delivery techniques of passive scattering and pencil beam scanning and clinical outcomes. The review evaluated the promising clinical outcomes of PT for Hodgkin lymphoma and Non-Hodgkin lymphoma, even more promising in the setting of relapsed/refractory disease, despite that the reports were often small number of patients by single institute.

The review also discussed the uncertainties of PT including RBE and variation caused by tissue density and target motion. Finally the review looked into comparison between proton and photon-based techniques for lymphoma patients, and concluded that a careful selection of patients who may benefit from PT, after a proper plan comparison with modern photon therapy might be a significant step towards.