This article summarized data of PRT for benign and malignant skull-base tumors including pituitary adenomas, craniopharyngiomas, benign meningiomas, vestibular schwannoma, sinonasal tumors, chordoma and chondrosarcoma. High local control rates and fewer toxicities produced by PRT have been reported. Common complications such as neurocognition, second malignancy, radiation-induced injuries to the brainstem, temporal lobe and optic pathway as well as mitigation strategies were discussed.