By Langendijk et al, this article presents the 'work package 1' of the European Proton Therapy Network (EPTN WP1). In order to establish a firm basis for evidence-based particle therapy at the European level, this work package will set up a worldwide prospective data registration programme for nine different tumour sites. This programme aims to provide more insights into the current practice and results across all European particle therapy centres with regard to radiation-induced toxicity and.

The prospective data registration provides major opportunities to continuously improve the quality of particle therapy, to synchronize selection criteria and to create more homogeneous patient cohorts to evaluate results. In addition, this proagramme will define the requirements for high quality clinical trials in order to enhance high quality clinical trial proposals and determine alternative methods for RCT, such as the model-based approach.