Subtitle
Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial.
Subtitle
Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial.
Proto therapy Time
November 2018
Executive summary
Patients with low-grade glioma (LGG) have a prolonged survival expectancy, therefore long-term side effects caused by radiotherapy is a concern. This multicenter planning study compared treatment plans using intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) for 25 LGG patients having undergone postoperative radiotherapy.
This study reported that the low dose volume to the majority of OARs was significantly reduced when using IMPT compared to VMAT. Whether this will lead to a significant reduction in neurocognitive decline and improved quality of life is to be determined in carefully designed future clinical trials.
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